Malignant transformation of oral lichen planus We conclude that the risk of malignant transformation in OLP is real but not high. Clinicians should have a higher index of suspicion of the possibility of malignancy developing in OLP, because such patients are different from typical patients who develop oral malignancy Malignant Transformation of Oral Lichen Planus and Oral Lichenoid Lesions: A Meta-Analysis of 20095 Patient Data A small subset of OLP patients (1.1%) develop OSCC; therefore, regular follow-up for these patients is recommended The malignant transformation of oral lichen planus and oral lichenoid lesions: a systematic review A small subset of patients with a diagnosis of OLP eventually developed SCC
Objective: The aim of this study was to systematically review the literature to determine: (a) the malignant transformation rate (TR) of oral lichen planus (OLP) and its risk factors; (b) whether or not oral lichenoid lesions (OLL) have a different malignant TR. Materials and methods: PubMed, Scopus, and Web of Science were used as search engines: only observational, full-length, English. Oral lichen planus (OLP) is a chronic inflammatory disease of unknown etiology with significant impact on patients' quality of life. Malignant transformation into oral squamous cell carcinoma (OSCC) is considered as one of the most serious complications of the disease; nevertheless, controversy still persists Aims: To investigate the malignant potential of oral lichen planus (OLP), a common mucocutaneous disease of unknown aetiology.The malignant potential of OLP is still controversial, with studies reporting malignant transformation rates of between 0 and 5.6%. We also aimed to identify factors that might be associated with malignant transformation The Malignant Transformation of Oral Lichen Planus and Oral Lichenoid Le-sions, a Case Report and Review of the Literature Selene Saraf*, Nadereh Ghanee DMD, Mary Nathanson Kilo MD, Abeer Alkhalidi DMD Pacific Northwest Kaiser Dental, U.S.A Research Open Access Journal of Clinical and Anatomic Patholog Oral lichen planus (OLP) is associated with risk for developing oral squamous cell carcinoma (OSCC). We performed a 7-year prospective study to assess the incidence of malignant transformation of OLP among adults
Introduction. Oral lichen planus (OLP) is an autoimmune chronic inflammatory disease of unknown etiology, characterized by the presence of white reticular lesions sometimes accompanied by erosive and/or atrophic lesions .Most authors consider it a highly prevalent disorder that may develop in up to 2% of the general population .OLP is currently considered an oral potentially malignant disorder. Objectives. For over a century, a heated debate existed over the possibility of malignant transformation of oral lichen planus (OLP). We performed this meta-analysis to evaluate the malignant potential of OLP and oral lichenoid lesions (OLL) and investigate the possible risk factors for OLP malignant transformation into oral squamous cell carcinoma (OSCC)
Ninety-two of 6,559 patients developed oral squamous cell carcinoma, with an overall TR of 1.40% (1.37% for OLP and 2.43% for OLL), an annual TR of 0.20%. Female gender, red clinical forms, and tongue site seem to slightly increase the transformation risk Keywords: Oral lichen planus, Oral squamous cell carcinoma, Malignant transformation, Retrospective study Background Oral lichen planus (OLP) is a chronic inflammatory oral mucosa disease of unknown etiology that has an estimated global prevalence of 1.01% [ 1 ]
Malignant transformation of oral lichen planus: a retrospective study of 565 Japanese patients Fumihiko Tsushima 1*, Jinkyo Sakurai1, Atsushi Uesugi1,2, Yu Oikawa 1, Toshimitsu Ohsako 1, Yumi Mochizuki 1, Hideaki Hirai1, Kou Kayamori3 and Hiroyuki Harada1 Abstract Background: Oral lichen planus (OLP) is a chronic inammatory oral mucosa disease. 1. Int J Oral Surg. 1985 Dec;14(6):509-16. Malignant transformation in oral lichen planus. Lind PO, Strømme Koppang H, Aas E. A carcinoma arose in the buccal mucosa of a 71-year-old woman suffering from several systemic diseases, and on extensive medication. The buccal mucosa had been affected by oral lichen planus for more than 9 years Introduction. Lichen planus is a chronic mucocutaneous inflammatory disease of unknown etiology, frequently occurring in oral locations, with distinctive though not entirely diagnostic clinical and histopathological characteristics. 1 One of the most controversial aspects of oral lichen planus (OLP) is its malignant potential.2, 3 Various studies have suggested that OLP has potential for. Oral lichen planus (OLP) is an immune-mediated mucocutaneous disease associated with an increased risk in oral squamous cell carcinoma (OSCC). Nearly all cases of malignant transformation have been reported in patients >40 years old. We report the case of a 37-year-old woman with a 5-year history of erosive OLP who presented with malignant.
DISCUSSION: Oral lichen planus (OLP) is an oral subtype of lichen planus with a prevalence in the world population estimated between 0.22% and 5% and an incidence approximately of 2.2%. The analysis of our results revealed an important information about the prevalence of malignant transformation, which is 9.37% Oral lichen planus (OLP) is T cell-mediated chronic inflammatory disease of the oral mucosa. In the erosive form, the lesions tend to be multifocal, ulcerative, and painful. 1 Patients with OLP have an increased risk of developing oral squamous cell carcinomas (OSCCs), with a reported malignant transformation rate between 0% and 5.3%. 2 Lesions in the tongue and buccal mucosa are most likely. Oral lichen planus: the evidence regarding potential malignant transformation. Krutchkoff DJ, Cutler L, Laskowski S. A critical review of the literature was undertaken to determine if there is valid data to support the contention that oral lichen planus represents a disease with significant potential for malignant degeneration Since oral lichen planus is considered a pre-malignant condition, a recall system has been recommended one to four times annually to facilitate the early diagnosis of malignant transformation
oral lichen planus (OLP) as having an increased potential for malignant development. The reported transformation rates vary from 0 to 9%. Several studies have been conducted recently, and there is a need for an updated review to re-assess available information to arrive at proper guidelines for the management of OLP Malignant transformation of oral lichen planus and oral lichenoid lesions: A meta-analysis of 20095 patient data. Aghbari SMH, Abushouk AI, Attia A, Elmaraezy A, Menshawy A, Ahmed MS, Elsaadany BA, Ahmed EM. Oral Oncol, 92-102 2017 MED: 2843830
The frequency and malignant transformation rate of oral lichen planus and leukoplakia--a retrospective study. Coll Antropol. 2012;36:773-77. 14. Bandyopadhyay A, Behura SS, Nishat R, Dash KC, Bhuyan L, Ramachandra S. Clinicopathological Profile and Malignant Trans-formation in Oral Lichen Planus: A Retrospective Study. J Int So Oral lichen planus and lichenoid reactions: etiopathogenesis, diagnosis, management and malignant transformation Sumairi B. Ismail1,2), Satish K. S. Kumar1,3) and Rosnah B. Zain1) 1)Department of Oral Pathology, Oral Medicine and Periodontology, Faculty of Dentistry, University of Malaya, Kuala Lumpur, Malaysi
F. Agha-Hosseini, N. Sheykhbahaei, and M.-S. SadrZadeh-Afshar, Evaluation of potential risk factors that contribute to malignant transformation of oral lichen planus: a literature review, The Journal of Contemporary Dental Practice, vol. 17, no. 8, pp. 692-701, 2016. View at: Publisher Site | Google Schola Oral leukoplakia, oral submucous fibrosis, and oral erythroplakia are the most common oral mucosal diseases that have a very high malignant transformation rate. Oral lichen planus is one of the potentially malignant disorders that may be seen in six different subtypes including papular, reticular, plaque-like, atrophic, erosive, and bullous. Studies of the malignant potential of oral lichen planus (OLP) have been hampered by inconsistencies in the diagnostic criteria used for OLP, the criteria adopted to identify a true case of malignant transformation in OLP, the risk factors for malignant transformation and the optimum management of patients to ensure the early diagnosis of transformation
Oral Lichen Planus and Malignant Transformation. There is no increased risk of skin malignancy in patients with cutaneous LP, but there is a higher risk in OLP, especially in men.  The. AIMS: To investigate the malignant potential of oral lichen planus (OLP), a common mucocutaneous disease of unknown aetiology. The malignant potential of OLP is still controversial, with studies reporting malignant transformation rates of between 0 and 5.6%. We also aimed to identify factors that might be associated with malignant transformation PD, van der Waal I. A review of the recent literature regarding 3. Bouquot JE, Gorlin RJ. Leukoplakia, lichen planus and other oral malignant transformation of oral lichen planus. Oral Surg Oral Med keratosis in 23,616 white Americans over the age of 35 years. Oral Surg Oral Pathol Oral Radiol Endod 1999;88:307-10
International Journal of Oral-Medical Sciences (2007) A review of the recent literature regarding malignant transformation of oral lichen planus Editors: Jed Jacobso Background: Oral squamous cell carcinoma (OSCC), the most common of all mucosal malignancies presenting in the head and neck (>90%), is estimated internationally to represent ~2% of the world's malignant neoplasms. 1-3 In 2005, the World Health Organization (WHO) recognized oral lichen planus (OLP) as a premalignant condition. 4 The characteristics of OLP undergoing malignant transformation. Oral lichen planus (OLP) is an immune-mediated mucocutaneous disease associated with an increased risk in oral squamous cell carcinoma (OSCC). Nearly all cases of malignant transformation have been reported in patients >40 years old Review Article Markers of Oral Lichen Planus Malignant Transformation Mircea Tampa,1,2 Constantin Caruntu ,3,4 Madalina Mitran,1,2 Cristina Mitran,1,2 Isabela Sarbu ,2 Laura-Cristina Rusu ,5 Clara Matei,2 Carolina Constantin ,6,7 Monica Neagu ,6,7,8 and Simona-Roxana Georgescu1,2 1Victor Babes Clinical Hospital for Infectious Diseases, 281 Mihai Bravu, 030303 Bucharest, Romani
The association of oral lichen planus (OLP) lesions with malignant transformation risk has remained a controver-sial topic and is of clinical importance. Therefore, the present study evaluated the expression levels of p16, Ki-67, budding uninhibited by benzimidazoles 3 (Bub -3) and sex -determinin and clinical features of the patients with OLP. Malignant transformation rate was 0.74%. Keywords: oral lichen planus; malignant transformation; clinical features 1. Introduction Oral lichen planus (OLP) is the chronic or recurrent autoimmune disease of the oral mucosa . Although the etiopathogenesis of OLP is unknown the immune system play presentation, oral findings, diagnosis, malignant transformation potential, and treatment of OLP. Introduction Oral lichen planus is a chronic mucocutaneous disease affecting stratified squamous epithelium. Oral reticular lichen planus (OLP) is thought to be quite common, nearly 1-2% of the population is affected.[1 BACKGROUND Determining the potential for malignant transformation of oral lichen planus (OLP) is complicated by difficulties in diagnosis, differentiation from oral lichenoid lesions (OLLs) and the phenomenon of premalignant lesions' exhibiting lichenoid characteristics. The authors of this systematic review evaluated evidence regarding malignant transformation of OLP and characterized. . Although oral lichen planus is a benign disorder, 1.4% of oral cavity lesions undergo malignant transformation within 7 years.3 Risk factors for malignant transformation include ulceration, location on the tongue and female sex.
5. Krutchkoff DJ, Cutler L, Laskowski S. Oral lichen planus: the evidence regarding potential malignant transformation. J Oral Pathol. 1978;7:1-7. 6. Bombeccari GP, Guzzi G, Tettamanti M, et al. Oral lichen planus and malignant transformation: a longitudinal cohort study [published online ahead of print July 22, 2011]. Oral Surg Oral Med Oral. Oral lichen planus (OLP) affects 0.22%-5% of the population worldwide and is considered to be a relatively common, chronic, oral mucocutaneous inflammatory disease that is poorly understood
Clinical guidelines in early detection of oral squamous cell carcinoma arising in oral lichen planus: A 5-year experience By Stefano Fedele and Lorenzo Lo Muzio Oral lichen planus and malignant transformation: a longitudinal cohort stud (5) However, Oral Cancer Background Papers as many reports on lichen planus patients followed over time indicate a higher than expected rate of malignant transformation,(6) it is prudent practice to biopsy the lesion at the initial visit to confirm the diagnosis and to monitor it thereafter for clinical changes suggesting a premalignant or. Oral lichen planus and malignant transformation: a longitudinal cohort study [published online ahead of print July 22, 2011]. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011;112:328-334. 7. Eisen D. The clinical features, malignant potential, and systemic associations of oral lichen planus: a study of 723 patients. J Am Acad Dermatol. . Oral lichen planus is a chronic inflammatory condition, affecting various parts of oral cavity. The present article gives an indepth review on lichen planus. a systematic review was done on the malignant transformation rate of OLP. They found a 1.37% chance of OLP turning into malignancy
There has been a continuous debate regarding the possible malignant potential of oral lichen planus (OLP). Based on the results from follow-up studies, OLP is regarded by several authors as a pre-malignant condition, and patients with OLP have been recommended to have their lesions monitored two to four times annually. This recommendation needs reconsideration, because a recall system of all. Oral Lichen Planus Part II: Therapy and Malignant Transformation Ana Líbia Cardozo Pereira, MD; Claudio de Moura Castro Jacques, MD; Marcia Grillo Cabral, DrOdont, MS, CD; Abel Silveira Cardoso. Keywords: oral lichen planus, lichenoid dysplasia, malignant transformation, OLP etiology, conjunctival, rheumatic heart disease Introduction Oral lichen planus is a common chronic inflammatory mucocutaneous disorder that typically affects the oral mucosa and additionally, in some cases the skin
Background Oral lichen planus (OLP) lesions have an overall malignant transformation rate of 1.37%. In patients with chronic disease, the diagnosis of malignancy relies on histopathological examination guided by clinical suspicion. Narrow-band imaging (NBI) is a promising endoscopic technique which, using a filtered light with specific wavelengths, can highlight microvascular abnormalities. . 3.1. Apoptosis-Related Biomarkers Fitzpatrick SG, Hirsch SA, Gordon SC: The malignant transformation of oral lichen planus and oral lichenoid lesions: a systematic review. J Am Dent Assoc. 2014; 145(1): 45-56. PubMed Abstract | Publisher Full Text ; 44 Lichen planus is a relatively common inflammatory disorder which may have cutaneous and or mucosal manifestation. The malignant potential of oral lichen planus is still debatable. Some authors are sceptical about the premalignant nature of the disease, while other investigators have reported that malignant transformations occur in 1-10% of the. Background: Oral potentially malignant disorders, which include oral lichen planus (OLP), are clinical presentations that carry a risk of development to cancer in the oral cavity. Oral lichenoid lesions (OLLs) are also termed interface/lichenoid mucositis. Malignant transformation of them remains controversial, but distinct clinical and histological criteria for how to differentiate OLP from.
Oral Lichen Planus Part II: Therapy and Malignant Transformation . Odontologic follow-up is indicated for all patients with a diagnosis of oral lichen planus (OLP). Replacing amalgam or gold. Oral Lichen Planus Has a Very Low Malignant Transformation Rate: A Systematic Review and Meta-Analysis Using Strict Diagnostic and Inclusion Criteria J. Oral Pathol. Med. 2021 Mar 01;50(3)287-298, M Idrees, O Kujan, K Shearston, CS Farah From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine Fitzpatrick SG, Hirsch SA, Gordon SC. The malignant transformation of oral lichen planus and oral lichenoid lesions: a systematic review. J Am Dent Assoc. 2014 Jan. 145 (1):45-56. . Shavit E, Hagen K, Shear N. Oral lichen planus: a novel staging and algorithmic approach and all that is essential to know. F1000Res. 2020. 9: Regarding the 8 patients who were diagnosed with oral squamous cell carcinoma, only 4 of them [16,19] had a previous biopsy confirming the oral lichen planus; therefore, only 50% of the patients presented malignant transformation had a previous histopathological confirmation of oral lichen planus Bcl-2 expression and its possible influence on malignant transformation of oral lichen planus. J BUON. PURPOSE: The aim of this study was to investigate the malignant potential of oral lichen planus (OLP) on the basis of the expression of the Bcl-2 marker in healthy individuals (H), patients with OLP and patients with squamous cell.
Oral lichen planus (OLP), characterized by a chronic mucocutaneous inflammatory condition, is a common disease of the oral cavity. Retrospective and prospective epidemiological data suggest that OLP is considered to have malignant potential. However, it is unclear as to which types of molecules may cause malignant transformation of OLP. In the present study, the presence of myeloid cell. The malignant trans-formation of oral lichen planus and oral lichenoid lesion: a sys-tematic review. JADA. 2014;145:45-56. 8. Hsue SS, Wang WC, Chen CH, et al. Malignant transformation in 1458 patients with potentially malignant oral mucosal disorders. J Oral Pathol Med. 2007;36:25-29. 9. Rodstrom PO, Jontell M, Mattson U, Holmberg E. Cancer. A quantitative expression of KI-67 to assess the malignant transformation potential in oral leukoplakia and erosive lichen planus Haranath Danda, Poosarla C Pusarla, Gontu S Reddy, Kattappagari K Kumar, Lalith P Chandra, Baddam V R Reddy Department of Oral Pathology and Microbiology, SIBAR Institute of Dental Sciences, Tekallapadu, Guntur, Andhra Pradesh, Indi
These authors evaluated 719 oral lichen planus cases diagnosed at the Oral Clinical and Pathology Unit II, Dentistry School, Buenos Aires University, Argentina, between 1991 and 1997, and found that all the 32 cases of malignant transformation (6,51%) occurred in atypical forms of lichen planus, such as presentation in the plaque, the erosive. 2. Oral Lichen Planus Aka Lichen Rubber Planus First described clinically :- 1869 - WilsonFirst described histologically by:- 1906 - Dubreuilh. 3. Erasmus Wilson (1869)-Mixed non Scrapable Red andwhite lesion in the mouth-Can occur individually or with skinlesions *Lichen in Greek - tree moss *Planus in Latin - flat. 4 Malignant Transformation in Oral Lichen Planus and Lichenoid Lesions: A 14-Year Longitudinal Retrospective Cohort Study of 829 Patients in New Zealand Oral Surg Oral Med Oral Pathol Oral Radiol 2020 Oct 01;130(4)411-418, G Guan, L Mei, A Polonowita, H Hussaini, B Seo, AM Rich From MEDLINE®/PubMed®, a database of the U.S. National Library of. .8%) at sites previously diagnosed by clinical examination as erosive or erythematous lichen planus. CONCLUSIONS: Patients with OLP usually display lesions with distinctive clinical morphology and characteristic distribution but may also present with a confusing array of forms and patterns. A review of the recent literature regarding malignant transformation of oral lichen planus. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1999;88:307-10. 35
The development of squamous cell carcinoma is controversial but is the most feared complication of oral lichen planus. Studies of the malignant potential of oral lichen planus have been fraught with inconsistencies in the diagnostic criteria of oral lichen planus and the criteria adopted to identify a true case of malignant transformation Morbidity: In lichen planus, atropy and scarring are seen in hypertrophic lesions and in lesions on the scalp. Cutaneous lichen planus does not carry a risk of skin cancer, but ulcerative lesions in the mouth, particularly in men, do have a higher incidence of malignant transformation. However, the malignant transformation rate of oral lichen.