Congenital granular cell tumor (congenital epulis) describes a different tumor of uncertain histogenesis affecting primarily the alveolar ridge in neonates (J Oral Maxillofac Pathol 2013;17:440 Granular cell tumors (GCTs) are uncommon tumors that occur at a wide variety of sites 1, 2 and are characterized by granular, acidophilic cytoplasm that contains abundant lysosomes 3 on ultrastructural examination. Although a wide variety of tumors may exhibit these light microscopic features, virtually all examples of true GCTs show strong S-100 protein expression immunohistochemically, and. Cytology of endobronchial granular cell tumor. Mermolja M(1), Rott T. Author information: (1)University Institute of Diseases of the Chest, Golnik, Yugoslavia. Cytologic features of four cases of endobronchial granular cell tumor are presented. The diagnostic cells were found in bronchoscopically obtained material Granular cell tumor (GCT) of the thyroid is rare. cases of thyroid GCT have been reported, none of which presented a cytopathological examination. In this paper, we report the fine needle aspiration cytology and pathological analysis of a thyroid GCT from a 12-year-old girl wh
Background: Malignant granular cell tumors (GCT) are the rarest of all sarcomas, and the histologic differentiation from their benign counterpart may be extremely difficult or impossible unless metastatic disease is demonstrated. To our knowledge, this is the first report of a malignant GCT diagnosed by fine needle aspiration (FNA) cytology Granular cell tumors (GCTs) are rare lesions in the breast of putative schwannian origin. These tumors are found in multiple sites throughout the body and have a characteristic histologic appearance. Recognition of these usually benign tumors is important since clinically, radiologically, and grossl Most reports on the cytologic features of granular cell tumors have been on lesions from the breast or respiratory tract. However, there are only a few reports on fine needle aspiration (FNA) cytologic diagnosis of cutaneous or soft tissue granular cell tumors
32 year old woman with pulmonary malignant granular cell tumor (World J Surg Oncol 2003;1:22) 42 year old woman with granular cell tumor of the lung (Lung 2010;188:355) 55 year old woman with coexistent pulmonary granular cell tumor and adenocarcinoma of the lung (Transl Lung Cancer Res 2014;3:262) 60 year old man with primary bronchial granular cell tumor (Korean J Thorac Cardiovasc Surg 2014. Cytology description Highly cellular, large cohesive groups and single cells mixed with connective tissue Cells have ill defined, abundant granular cytoplasm and bland small nuclei with prominent nucleoli No mitotic figures, no necrosis (Diagn Cytopathol 2007;35:725
Background: Granular cell tumors (GCT) formerly known as Abrikossoff tumor or granular cell myoblastoma, are rare neoplasms encountered in the fine needle aspiration (FNA) service. Named because of their highly granular cytoplasm which is invariably positive for the S-100 antibody, the classic GCT is thought to be of neural origin . Based on histochemical reactivity for S-100 protein and ultrastructural characteristics, GCT histogenesis favors a Schwann cell origin and is characterized by large cells with a highly granular cytoplasm [ 1 - 3 ]. GCT has been reported in many locations, especially the head and neck [ 2 ]
Granular cell tumors (GCTs) are uncommon neoplasms with recently postulated origin from Schwann cell or neural crest. It can appear in different parts of the body and is most commonly found in the tongue. The cutaneous presentation is not that uncommon. Fine needle aspiration cytology (FNAC) has been suggested to be the diagnostic modality of. Metastatic granular cell tumor to the breast diagnosed by fine needle aspiration cytology: A case report with review of the literature. Mir F(1), Alnajar H(2), Rohra P(1), Naumaan A(1), Cheng L(1), Gattuso P(1). Author information: (1)Department of Pathology, Rush University Medical Center, Chicago, Illinois Mast cell tumors (Figure 9) are the most common skin tumor in dogs. 10 They can occur as single or multiple skin tumors and occasionally infiltrate the abdominal organs and bone marrow. Mast cell tumors cannot be graded on cytology; histopathology is required. Aspiration of the draining lymph nodes may be beneficial to determine the potential. Granular cell tumor (GCT) of the thyroid is rare. Before this report, only four cases of thyroid GCT have been reported, none of which presented a cytopathological examination. In this paper, we.. Epidemiology. Accounts for 2% of all ovarian tumors and is the second most common ovarian sex cord stromal tumors after fibroma / thecomas. Most granulosa cell tumors are adult type (95%) and 5% are juvenile type. Wide age range; most common in postmenopausal women with peak age 50 - 55
Granular cell tumors (GCTs) are uncommon soft tissue tumors, which are difficult to diagnose merely on clinical examination. Being an effective first-line investigation, the fine-needle aspiration cytology (FNAC) plays a significant role in its pre-operative recognition cytology, histopathology, immunohistochemistry, electron microscopy) indicated that the tumor was an intratesticular granular cell tumor. Granular cell tumor has not been described in rabbits before and has not been described in the testes of animals or postnatal humans. Granular cell tumor should be include Granular cell lesions of the oral mucosa, jaws, and salivary glands constitute a heterogeneous group of lesions which may be either odontogenic, salivary gland, or metastatic in origin. Granular cells in these proliferations most commonly are the result of lysosomal accumulation, aging, degenerative, metabolic alteration, increased apoptosis, cytoplasmic autophagocytosis, and many more Malignant granular cell tumor (MGCT) is a rare high-grade mesenchymal tumor of Schwann cell origin. MGCTs commonly affect thigh, extremity, and trunk; however, involvement of the abdominal wall is quite rare. It has poor prognosis with 39% mortality rate in 3-year interval. We report a 50-year-old female who had MGCT arising in the anterior abdominal wall and developed massive metastatic.
Granular cell tumor has a characteristic cytological appearance, and fine-needle aspiration cytology has been suggested to be diagnostic modality of choice. View Show abstrac IMAGES IN CYTOLOGY. Granular cell tumor of the lung. Elizabeth B. Finer, University of Rochester (Pre-medical student, summer intern for Dr. Pitman), Rochester, New York. Search for more papers by this author. Julian A. Villalba MD, Corresponding Author
Fine needle aspiration cytology and histologic findings of granular cell tumor of the breast: review of 19 cases with clinical/radiologic correlation. The Breast Journal, 6 , 27-30. CrossRef PubMed Google Schola The cytological features of granular cell tumour (GCT) are generally quite typical but, in some cases, the fine needle aspiration cytology (FNAC) diagnosis of GCT may be difficult or impossible because of unusual sites of onset or equivocal cytological features. In this report, two GCTs with atypical FNAC features are described in order to. 12. Ventura L, Guadegni S, Ventura T, et al. Benign granular cell tumour of the breast: a misleading disease. Tumori 1999; 85: 194â€8. 13. Gibbons D, Leitch M, Coscia J, et al. Fine needle aspiration cytology and histologic ï¬ ndings of granular cell tumor of the breast: review of 19 cases with clinical/radiologic correlation Fine-needle aspiration cytology of granular cell tumor: A report of two cases Access this article online Website: www.jcytol.org Quick Response Code DOI: 10.4103/0970-9371.11764
The granular cell tumor (GCT) represents a rare but important lesion in the differential diagnosis of breast tumors. Since this generally benign tumor may be misdiagnosed as malignant in clinical investigation, mammography, sonography, and even in frozen sections, a preoperative diagnosis is of utmost importance Very Granular Cytoplasm • Granular cell tumor (lysosomes) • Acinar cell carcinoma (zymogens) • Oncocytic/Hürthle cell neoplasms (mitochondria) • Neuroendocrine tumors (neurosecretory granules) • Hepatocytes/tumors • Melanoma (melanosomes) • Adrenal cortical/tumors • Leydig cells/tumors Cytology of endobronchial granular cell tumor Mermolja, Milivoj; Rott, Tomaž 1991-09-01 00:00:00 Cytologic features of four cases of endobronchial granular cell tumor are presented. The diagnostic cells were found in bronchoscopically obtained material. They were arranged in smaller clusters and had finely granular cytoplasm with uniform oval.
Introduction. Granular cell tumor (GCT) is an uncommon neoplasm. It can appear in different parts of the body and is most commonly found in the tongue. The cutaneous presentation is not that uncommon.[2,3] The cutaneous tumor presents as solitary painless nodule in the subcutis or dermis and less frequently in the striated muscle.Breast is another common site.[ Granular Cell Tumor, Bland Cytology (Right) Oil immersion image shows the bland cytologic features of a granular cell tumor at very high magnification. The tumor cells have smooth nuclear membranes and small nuclei. Mitoses are seldom encountered, except in rare malignant forms Granular cell tumor: case report. Journal of the Saudi Society of Dermatology & Dermatologic Surgery. 2011;15(1):25-27. 3. Avninder Singh, Manav Sawhney and SD. Granular cell tumor of skin diagnosed on fine needle aspiration cytology. Indian J Dermatol. 2012;57(4):330-331. 4. Park JY, Hwang JJ, Lee SA, et al. Granular cell tumor occurring.
Granular cell tumors (GCT) are uncommon soft tissue neoplasms that may be asymptomatic or may present as a slow growing nodule. It is usually diagnosed based on its characteristic cytological and histomorphological features. We present a case of granular cell tumor in the right inguinal region misdiagnosed as a reactive lymph node on cytology 614 Duncan and Prasse Materials and Methods Retrospective study of the cytology of canine cutaneous round cell tumors was conducted on 64 cases which were selected for study if a complete physical and histologic examination had been conducted.The final diagnosis was made after consideration of findings from all the procedures. The selected cases included 25 mast cell tumors, 15 histiocytomas. Read Fine Needle Aspiration Cytology and Histologic Findings of Granular Cell Tumor of the Breast: Review of 19 Cases with Clinical/Radiologic Correlation, The Breast Journal on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips
Granular cell tumors (GCT) are mesenchymal neoplasms of Schwann cell/neural origin. Malignant granular cell tumors (MGCTs) represent <1‐2% of all GCT and defined as tumors demonstrating metastases or destructive local growth. Other clinical parameters suggestive of malignancy include rapid growth, size > 4 cm and necrosis Fine needle aspiration cytology diagnosis of a cutaneous granular cell tumor in a 7-year-old child. Acta Cytol 2001;45:263-6. 3. Liu K, Madden JF, Olatidoye BA, Dodd LG. Features of benign granular cell tumors on fine needle aspiration. Acta Cytol 1999;43:552-7 Malignant granular cell tumor (MGCT) is a rare high-grade mesenchymal tumor of Schwann cell origin. MGCTs commonly affect thigh, extremity, and trunk; however, involvement of the abdominal wall is quite rare. It has poor prognosis with 39% mortality rate in 3-year interval. We report a 50-year-old female who had MGCT arising in the anterior abdominal wall and developed massive metastatic. On cytology, histiocytomas are in the round cell tumor category. They may be confused with other round cell tumors, such as plasma cell tumors or poorly granulated MCTs. Despite their benign behavior, histiocytomas often exhibit cytologic features of malignancy, such as numerous mitotic figures and marked anisocytosis (Figure 14). Caution needs. Cytology of endobronchial granular cell tumor. Mermolja M, Rott T. Diagn Cytopathol, (5):524-526 1991 MED: 1954834 Handbook of fine needle aspiration biopsy cytology. St. Louis: C. V. Mosby, 1981: 131-175. Show 7 more references (10 of 17) Citations & impact . Impact metrics. 9.
INTRODUCTION. A granular cell tumor (GCT) is an uncommon tumor with an incidence of 0.017-0.029% in general surgical specimen.[1-4] It was first described in 1926 as granular cell myoblastoma by Abrikossoff.[4-8] Though the most common site of involvement is the tongue, it can occur anywhere in the body.[3-5,9] A GCT usually presents as a small solitary painless firm nodule affecting the. Granular cell tumor is a rare tumor of the soft tissue and this is characterized by proliferation of large cells with granular appearing eosinophilic cytoplasm. We report the imprint cytologic features of a case of granular cell tumor in the left calf of a 52-year-old woman. Microscopic examination showed moderate cellularity Gingival granular cell tumor of newborns is an extremely rare variant and manifests as a polypoid swelling situated exclusively over the lateral alveolar ridge, especially of the maxilla. More than 90% of patients are girls. [ 21] These lesions are likely to be reactive rather than neoplastic in nature, and, ultimately, they may be segregated.
Granular cell tumors (GCTs) have a characteristic cytological appearance, and fine-needle aspiration cytology (FNAC) has been suggested to be the diagnostic modality of choice. However, the differential diagnosis has not yet been well described. We herein describe a rare case of GCT of the breast and discuss the differential diagnosis. A 53-year-old woman presented to our hospital with a left. Granular cell tumors (GCT) are uncommon, generally benign soft tissue neoplasms that can affect virtually any site of the body, the most common locations being tongue, breast, upper respiratory tract, skin and soft tissues of upper extremities. Cytology, Atypical granular cell tumor, FNAC, Soft tissue neoplasms, Immunocytochemistry
Granulosa cell tumor of the ovary is a rare type of ovarian cancer that accounts for approximately 2% of all ovarian tumors. This type of tumor is known as a sex cord-stromal tumor and usually occurs in adults. Granulosa cell tumors of the ovary cause higher than normal levels of estrogen in a woman's body. The symptoms of this excess estrogen depend on the woman's menstrual status; the most. Granular cell tumor of hand presenting as subcutaneous nodule mimicking dermal adnexal tumor: A diagnosis by cytology Jitendra G Nasit 1, Sanjaykumar Chauhan 2, Gauravi Dhruva 1 1 Department of Pathology, P. D. U. Government Medical College and Hospital, Rajkot, Gujarat, India 2 Department of Pathology, GMERS Medical College-Gotri, Vadodara, Gujarat, Indi
In addition to Melan A, balloon cell melanomas may stain for S-100 and neuron-specific enolase.(1,11) Rhabdomyomas, oncocytomas and granular cell tumors have a similar cytologic appearance with eosinophilic granular material in the cytoplasm, comparable to what is seen in a subset of cells in this case The finely granular cytoplasm observed in some hibernomas may simulate a benign granular cell tumor. 34-36 The lack of a mature lipomatous component as well as the absence of both typical multivacuolated brown fat-like cells and a delicate vasculature help to distinguish granular cell tumors from hibernomas This report is concerned with the fine-needle aspiration (FNA) diagnosis of the granulosa cell tumor in the latter site and corroboration of the interpretation by immunocytochemistry. Only one previous case is similar to the present one documenting the role of immunocytochemistry in the evaluation of suspected metastatic granulosa cell tumor Granular cell tumor (GCT) is an uncommon type of neoplasm composed of cells in granular cytoplasm, which was described for the first time in 1926 by the Russian pathologist, Aleksei I. Abrikossoff, as 'granulosa cell myoblastoma' of a myogenic origin .However, recent immunohistochemical studies have suggested that GCTs are of Schwann cell origin  First, this was the second reported case of unusual granular cell tumor of the trachea coexisting with papillary thyroid carcinoma. 3 Second, we initially misdiagnosed this patient as having tracheal invasion from recurrent thyroid carcinoma even after a CT scan and fine-needle aspiration cytology. Misdiagnosis occurred as the patient had a.
DISCUSSION: Granular cell tumor is a mesenchymal tumor, probably of Schwann cell origin, with tumor cells showing abundant eosinophilic granular cytoplasm. (1) The first report of granular cell tumor is attributed to Abrikossoff in 1926 localized in the tongue and he proposed origin from striated muscle cells and he termed this lesion as. Abstract. Granular cell tumor rarely occurs in the thyroid. This case report describes the cytologic features of a granular cell tumor seen in a fine needle aspirate obtained from a 27-year-old woman with a gradually enlarging thyroid nodule. The aspirate showed single as well as syncytial clusters of cells with abundant granular cytoplasm We report a case of granular‐cell tumor (GCT) in the esophagus. This is a rare location for this tumor and only 80 cases have been described. The tumor was diagnosed in a 24‐yr‐old woman with epigastralgia. Endoscopic examination revealed a submucosal ulcerated lesion. The smears derived from esophageal brushings contained clusters of granular cells recognize the cytologic features of granular cell tumor (GCT) of the breast in a cytology specimen; distinguish characteristics of GCT from other entities in the breast; formulate a differential diagnosis for benign and malignant lesions with granular and oncocytic features in breast cytology
Granular cell tumor (GCT) also known as Abrikossoff's tumor is an uncommon soft tissue tumor of neurogenic origin. GCT of the breast accounts for < 0.1% of breast tumors and 6% of all reported cases of granular cell tumor. Although GCT is a benign tumor, malignant GCT can be seen in 1% v of the cases. GCT of the breast is diagnostically challenging as it can imitate carcinoma clinically and. Exfoliative Cytology of a Case of Bronchial Granular Cell Myoblastoma. Über Myome, Ausgehend von der Quergestreiften Willkürlichen Muskulatur,. in 1926, but only seven, including the present case, were found in the bronchial tree. The histogenesis of this tumor is obscure; many theories have been proposed Higher grade tumors can be poorly or well-granulated and nuclear criteria of malignancy (nuclear atypia, binucleation, large nuclei, mitotic figures) are more reliable than granularity for determining the grade of mast cell tumors on cytology. Tumor grading for dermal (not subcutaneous) mast cell tumors in dogs is best done by histopathology Granular cell tumors are rare soft tissue tumors; they are almost never malignant, but can mimic a carcinoma. Differential diagnosis of Granular cell tumors is challenging in particular during follow up in a breast cancer patient. A misdiagnosis due to the fear of local or distant recurrence can be responsible for patient's overtreatment Granular cell tumors (GrCTs) are rare benign lesions of Schwannian origin composed of cells with abundant granular cytoplasm. GrCT was initially descried as myoblastoma in 1926 and thought to be originated from smooth muscle origin. Later, with the aid of immunohistochemical and ultrastructural studies, this has been changed into the neuronal origin
A case of granular cell tumor of the breast has been studied by cytology, histology and electron-microscopy. In cytological samples, granular cells with coarsely granular, ill defined cytoplasm were seen in clusters or in single. Angulated body cells with angular inclusion bodies were seen around or in the clusters of the granular cells Granular cell tumor of nasal cavity: An uncommon occurrence with review of literature - ACHR- Print ISSN No: - 2581-5725 Online ISSN No:- 2456-9267 Article DOI No:- 10.18231/j.achr.2020.067, IP Archives of Cytology and Histopathology Research-IP Arch Cytol Histopathol Re Cytoplasm vacuolated, occasionally granular: Cytoplasm granular : Indistince cytoplasmic borders : Sharp cytoplasmic borders: Small nuclei and nucleoli : Large vesicular nuclei with prominent nucleoli : Appears to have more aggressive behavior than usual carcinoma : Appears to have better behavior than usual carcinoma in some serie In 1997, Smith et al. described fine needle aspiration cytology findings of a mediastinal granular cell tumor in a 53 year-old woman 6. While they described the cytologic findings of a granular cell tumor, they failed to make a definitive, preoperative diagnosis of granular cell tumor utilizing ancillary studies on cytology material
granular cell tumor on cytology was labeled as fibro adenoma on histopathology. The histopathological correlation with malignant lesions on cytology as seen in present study indicated that out of the total 32 (100%) cases of IDC that had a histopathologica Journal of Clinical Medicine Article Use of Cytology in the Diagnosis of Basal Cell Carcinoma Subtypes Paola Pasquali 1,*, Gonzalo Segurado-Miravalles 2, Mar Castillo 3, Ángeles Fortuño 4, Susana Puig 3 and Salvador González 5 1 Dermatology Department, Pius Hospital de Valls, 43800 Tarragona, Spain 2 Dermatology Department, Hospital Ramón y Cajal, 28034 Madrid, Spain; email@example.com Granular cell tumors in the cerebral hemispheres are rare and of unknown origin. Two large aggressive cerebral neoplasms composed mainly of granular cells and also containing neoplastic astrocytes were studied histologically, ultrastructurally and immunohistochemically Introduction. Granular cell tumors (GCT) are relatively infrequent lesions that were initially described by Abrikossoff in 1926 as part of a series of five tumors of the tongue, which he called myoblastoma. 1 In 1931 he described the first case of this kind of neoplasia located in the esophagus 2 and since then some 300 cases of GCT have been documented. 3,
Neumann's Tumor Vs Abrikossoff's Tumor: Uncommon Neoplasm with Controversial Histiogenesis (Granular Cell Tumor) - ACHR- Print ISSN No: - 2581-5725 Online ISSN No:- 2456-9267 Article DOI No:- 10.18231, IP Archives of Cytology and Histopathology Research-IP Arch Cytol Histopathol Re Loncar B, Marjanović K, Pauzar B, Staklenc B, Granular cell tumorclinically presented as lymphadenopathyColl Antropol 2010; 34: 2613-3. Chung SY, Noh WC, Jin MS, Lee SS, Koh JS, Fine needle aspiration cytology of granular cell tumor in breast -A case reportKorean J Cytopathol 2007; 8: 15760-4. Sung JW, Choi JH, Imprint cytology of granular. Granular cell tumors (GCTs) are rare in domestic animals. They have been reported most commonly in dogs and horses, and there are several reports describing GCTs in cats and a bird. 4,8,11 Primary GCTs occur at several sites in the body, and in dogs these tumors are most commonly described in the oral cavity. Additionally, canine GCTs have been reported occasionally at other sites such as. Granular cell tumors (GCTs) are uncommon benign lesions which usually occur in head and neck region, with tongue being the most common site. Lesions involving nasal and paranasal areas are extremely rare. We report a case of GCT arising from left nasal cavity in a 15 year old female who presented with unilateral epistaxis since 4-5 months Ultrastructural features of the neoplastic cells included numerous secondary lysosomes and irregular pleomorphic nuclei. The final diagnosis was meningeal granular cell tumor. This case documents the cytologie and histologic features of an uncommon type of meningeal tumor. KW - Canine. KW - Cytology. KW - Granular cell tumor. KW - Meningiom We report on a case of extraluminal tracheal granular‐cell tumor which was interpreted as a Hurthle‐cell neoplasm of the thyroid on fine‐needle aspirate. Review of the literature reveals only one other such case. The patient was a 35‐yr‐old female who presented with an enlarged thyroid. Aspiration cytology revealed a syncytium of cells with abundant granular cytoplasm interpreted as.