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Mesalazine male fertility

Improve Your Sperm - Boost Male Fertility Naturall

  1. Mesalazine is a well-established treatment for ulcerative colitis. A young man treated with mesalazine for proctitis was found to have pathological semen with a count of only 3 x 10 (6) sperm cells/ml. He failed to achieve conception with his wife. When mesalazine treatment was stopped, semen analysis returned to near normal and pregnancy ensued
  2. e the effect of mesalazine on fertility. In this retrospective analysis of 1,225 male subfertile patients, we reviewed the cases of inflammatory bowel disease (IBD) in the medical records and evaluated the prevalence of the disease in our reproduction center
  3. Mesalazine is a well-established treatment for ulcerative colitis. A young man treated with mesalazine for proctitis was found to have pathological semen with a count of only 3×106 sperm cells/ml. He failed to achieve conception with his wife. When mesalazine treatment was stopped, semen analysis returned to near normal and pregnancy ensued
  4. One case study of a young male has reported reversible infertility owing to mesalazine. 36 Effects on pregnancy Mesalazine crosses the placenta, especially as the metabolite Nacetylmesalazine,..
  5. e) on sulfasalazine-induced impairment of male fertility was exa
  6. e the effect of mesalazine on fertility. In this retrospective analysis of 1,225 male subfertile patients, we reviewed the cases of inflammatory bowel disease (IBD) in.

Mesalazine-induced reversible infertility in a young mal

The use of sulfasalazine is the cause of oligo-astheno-teratospermia and infertility in over 60 % of treated men [ 57 ], although it is reversible after two months after stopping treatment Switching to mesalazine also restores male fertility, indicating that the sulfapyridine component is the culprit in sulfasalazine-induced infertility.20 Azathioprine does not impair male fertility,23 but its teratogenic potential, mainly attributed to its metabolite 6-mercaptopurine (6-MP), remains controversial Maintenance of fertility in men needing alkylating agents. As described in women, the most important alkylating agent used in male patients with rheumatic diseases is CYC. This drug may induce depletion of germinal epithelium ( 3 ) and cause damage in Sertoli cells ( 4 ) and in Leydig's cells ( 58 )

Sulphasalazine, a commonly used medication for IBD, causes reduced fertility in men. It also increases the risk of birth defects. Good alternatives to sulphasalazine, such as mesalazine, olsalazine or balsalazide, have the same effect on the colon without affecting fertility. Sperm Issues For Men With Crohn's Diseas Abstract Sulfasalazine (SASP) has been reported to depress the fertility in men and experimental male animals, but the fundamental mechanisms of infertility caused by SASP are still unknown

Inflammatory bowel disease in subfertile men and the

Mesalazine-induced reversible infertility in a young male

Fertility Animal data on mesalazine show no effect on male and female fertility. 4.7 Effects on ability to drive and use machines Treatment with PENTASA is unlikely to affect the ability to drive and/or use machines. 4.8 Undesirable effects Summary of the safety profil Azulfidine (sulfasalazine), which is used to treat ulcerative colitis, can affect male fertility. A temporary form of infertility is caused by the sulfa component of this drug in up to approximately 60 percent of men who take it. About two months after stopping Azulfidine, fertility goes back to what it was before the drug was started

4.6 Fertility, Pregnancy and Lactation. Effects on fertility. No effects on fertility or reproductive performance were observed in male or female rats at oral doses of mesalazine up to 400 mg/kg/day (0.7 times the maximum recommended human dose based on a body surface area comparison) Fertility: Animal data on Mesalazine show no effect on male and female fertility. 4.7 Effects on ability to drive and use machines. Pentasa Sachet has no or negligible influence on the ability to drive or use machines. 4.8 Undesirable effect Advise men with ulcerative colitis that: Fertility is unlikely to be affected for most men, however a history of pelvic surgery may lead to erectile dysfunction or ejaculatory problems. In addition, men who undergo ileo-anal pouch surgery may develop retrograde ejaculation and erectile dysfunction

Male fertility: Losing weight and cancer drugs 'boost

Background & Aims: Long-term treatment with azathioprine (AZA) is well established in inflammatory bowel disease (IBD). AZA is metabolized to 6-mercaptopurine (6-MP), which interacts in purine metabolism and is therefore considered to have mutagenic potentials. This is the first study to examine the influence of AZA on semen quality. Methods: Semen quality was examined and compared with World. Moreover, we have reported a retrospective study of the negative influence of mesalazine on fertility in men with IBD. In this study, 7 of 1225 male subfertile patients had received mesalazine. In 6 of them, mesalazine was discontinued and sperm motility and total motile sperm count were significantly improved In patients taking medications which may damage sperm quality, cessation may restore fertility. 56 However, the risk of stopping the medication to potentially regain fertility must be weighed against the health benefits derived from the medication. 48 In patients on sulfasalazine, it is recommended that patients switch to mesalazine at least 4.

to mesalazine also restores male fertility, indicating that the Azathioprine does not impair male fertility,23 but its teratogenic potential, mainly attributed to its metabolite 6-mercaptopurine (6-MP), remains controversial. Two studies have reported an increased incidence in congenital mal Mesalazine, glucocorticoids and thiopurines do not affect female or male fertility and can be used safely prior to and during pregnancy, as well as during lactation male fertility. The 205 pregnancies involving 152 trans-planted fathers who had been treated with mycophenolate were associated with a similar risk of prematurity (10 %) and malformations (3 %) as in the general population [19]. The AMH levels of female patients treated with myco-phenolate for lupus were not lower than in a control population [20] No effects on fertility or reproductive performance were observed in male or female rats at oral doses of mesalamine up to 400 mg/kg/day (0.8 times the recommended human dose based on body surface area). Semen abnormalities and infertility in men, which have been reported in association wit Mesalazine is used to treat ulcerative colitis and Crohn's disease and other types of inflammatory bowel disease.. It belongs to a group of medicines called aminosalicylates. These help to reduce redness and swelling (inflammation) and can help with healing

Mesalamine - MotherToBab

Men on sulfasalazine should therefore be transitioned to 5-ASAs at least four months prior to conceiving, as fertility is shown to be restored after stopping medication or switching to other mesalazine preparations 35,36 This substance appears to cause seminal disorders (oligospermia, reduced sperm motility and abnormal morphology) and infertility in 60% of men [19]. Replacement of this substance with mesalazine seems to also restore male fertility [20]. In addition, methotrexate has been demonstrated to be teratogenic [21] No effects on fertility or reproductive performance of the male and female rats were observed at oral mesalamine doses up to 320 mg/kg/day (about 1.7 times the recommended human intra-rectal dose of CANASA, based on body surface area). Use In Specific Populations Pregnancy Risk Summar Fertility: Animal data on Mesalazine show no effect on male and female fertility 4.7 Effects on ability to drive and use machines Pentasa Sachet has no or negligible influence on the ability to drive or use machines. 4.8 Undesirable effects. 4/5/2021 Pentasa Sachet 1g - Summary of Product Characteristics (SmPC) - print friendly - (emc). Fertility Data on mesalazine show no sustained effect on male fertility. 4.7 Effects on ability to drive and use machines No studies on the effects on the ability to drive and use machines have been performed. Mesavancol is considered to have negligible influence on these abilities

IBD and Male Infertilit

Mesalazine - Drug Information, Uses, Adverse Effects

Treatment with enteric-coated mesalazine allows the recovery of seminal abnormalities induced by sulphasalazine in patients with colitis. Full text Get a printable copy (PDF file) of the complete article (833K), or click on a page image below to browse page by page These results indicate significant roles for products of the COX-2 pathway in testicular vascular control and steroidogenesis, which may have implications for men with marginal fertility taking celecoxib for extended periods, but also highlight the potential of this drug to ameliorate testicular damage caused by systemic or local inflammation. Fertility, pregnancy and nursery: Conception and pregnancy are common events in the cohort of IBD patients, owing to the fact that many patients with IBD are of child-bearing age without diminished fertility, although SASP and anecdotically mesalazine have been associated with reversible, decreased male fertility[100,101] 5-ASA stands for 5-aminosalicylic acid. Another name for this class of drugs is aminosalicylates. Acetylsalicylic acid, the active ingredient in aspirin, is chemically related to the 5-ASA drugs. The 5-ASA medications control inflammation. They are important drugs for treating ulcerative colitis but are usually not as effective for Crohn's disease Effect on fertility Animal data on mesalazine show no effect on male and female fertility. There is no reference to the effect of meselazine on fertility in humans. Risk Management Plan on Date of the RMP Mesalazine / granules for rectal suspension December 2014 4/4 VI.2.5 Summary of additional risk minimisation measures by safety concern.

Immunosuppressive drugs and fertility Orphanet Journal

Carcinogenesis, Mutagenesis, Impairment of Fertility. Two-year oral carcinogenicity studies were conducted in male and female F344/N rats and B6C3F1 mice. Sulfasalazine was tested at 84 (496 mg/m 2), 168 (991 mg/m 2), and 337.5 (1991 mg/m 2) mg/kg/day doses in rats. A statistically significant increase in the incidence of urinary bladder. significantly lower fertility rates. Because methotrexate can cause abortion and congenital malformations, it should be stopped 3-6 months before conception in both men and women, and should not be taken while pregnant or breastfeeding. Pregnancy Mesalazine can affect fertility in men. Discuss this with your doctor. You may not notice the effects of mesalazine straight away - it can take several weeks before you start to feel better. You will need regular blood tests while taking mesalazine to check if it is causing problems with your liver, kidneys or blood

Management of inflammatory bowel disease in pregnancy

4 5 • Medications can be given in . oral. form (by mouth), intravenously (through a vein), or . subcutaneously (by injection under the skin). Topical therapies are administered rectally, a Sulfasalazine is a type of drug known as a disease-modifying anti-rheumatic drug (DMARD).It may be used on its own or with other drugs. Sulfasalazine changes the way your condition affects you, and reduces inflammation, pain and swelling in your joints Sulfasalazine can affect male fertility by reducing sperm count. This usually resolves within a couple of months of stopping treatment. If you are trying for a baby, you may need to be switched to a different type of 5-ASA medicine. You can drink alcohol in moderation whilst taking sulfasalazine, although it can sometimes aggravate nausea Therefore, Mesalazine NORDIC should only be used during breast-feeding, if the potential benefit outweighs the possible risk. If the infant develops diarrhoea, breast-feeding should be discontinued. Fertility: Animal data on Mesalazine show no effect on male and female fertility. 4.7 Effects on ability to drive and use machine

New Fertility section: 'Animal data on Mesalazine show no effect on male and female fertility' Section 4.7: sentence updated from 'None known' to 'Pentasa Sachet has no or negligible influence on the ability to drive or use machines.' Section 4.8: Changes to Rare events:- nervous system disorders: 'dizziness' adde <P>Background and Aims: Sexual functions are sometimes adversely affected by the therapeutic drugs delivered for treating IBD. Much attention has bee..

Maintenance of fertility in patients with rheumatic

Enhancement of the myelosuppressive effects of azathioprine or 6-mercaptopurine may occur rarely in patients who are treated concomitantly with mesalazine. 4.6 Fertility, Pregnancy and Lactation. Effects on fertility. Decreased sperm count and impaired sperm motility, which may affect male fertility, have been reported with mesalazine Fertility. Data on mesalazine show no sustained effect on male fertility. 4.7 Effects on ability to drive and use machines. No studies on the effects on the ability to drive and use machines have been performed. Mezavant is considered to have negligible influence on these abilities Thunder god vine is an herb. Its leaves and root are used to make medicine. Thunder god vine is used for rheumatoid arthritis (RA), a type of inflammatory bowel disease (Crohn disease), kidney. Mesalamine does not impair fertility in females with inflammatory bowel disease (Mahadevan 2019). Pregnancy Considerations Mesalamine (5-ASA) and the metabolite N-acetyl-5-aminosalicylic acid (Ac-5-ASA) cross the placenta (Klotz 1993) Male infertility may be caused by many diseases, conditions, and other factors. Experts differ on when genetic tests should be done. Coeliac disease and problems associated with reproduction. A support group or another patient your fertility specialist connects you with, these percentages are an approximate prevalence

IBD And Infertilit

Carcinogenesis, Mutagenesis, Impairment of Fertility: Two-year oral carcinogenicity studies were conducted in male and female F344/N rats and B6C3F1 mice. Sulfasalazine was tested at 84 (496 mg/m 2 ), 168 (991 mg/m 2 ), and 337.5 (1991 mg/m 2 ) mg/kg/day doses in rats Guidelines state that medical therapy for IBD, including mesalamine, does not decrease fertility. Experts and guidelines consider mesalamine compatible and safe for use during breast-feeding. In published lactation studies, maternal mesalamine doses from various oral and rectal formulations and products ranged from 500 mg to 3 g daily Ulcerative colitis. Adults. Active disease. Individual dosage, up to 4 g mesalazine once daily or divided into 2-4 doses. Maintenance treatment. Individual dosage Impairment of male fertility was observed in reproductive studies performed in rats at a dose of 800 mg/kg/day (4800 mg/m²). Oligospermia and infertility have been described in men treated with sulfasalazine. Withdrawal of the drug appears to reverse these effects

Effects of Sulfasalazine on Sperm Acrosome Reaction and

Autoimmune Diseases and Male Fertility: A Systematic

Effects on Fertility Decreased sperm count and impaired sperm motility, which may affect male fertility, have been reported with mesalazine. This effect may be reversible when treatment is discontinued. (see adverse reaction section The newer 5ASA- s i.e. mesalazine, osalazine and balsalazide are better tolerated than sulfasalazine2. In Nottinghamshiremesalazine is recommended as the first choice of 5 - Sulphasalazine is associated with a reversible reduction in male fertility, yellow-orange discoloration of skin, urine, and other body fluids. Precautions No effects on fertility or reproductive performance were observed in male or female rats at oral doses of mesalamine up to 400 mg/kg/day (0.8 times the recommended human dose based on body surface area) The adverse effects of smoking on male fertility are well documented. Tight-fitting underwear affects semen quality. Men should be informed that although there is an association between elevated scrotal temperature and reduced semen quality, it is still uncertain whether wearing loose-fitting underwear improves fertility There are a few ways in which you can preserve male fertility and sperm count. Follow these top tips: ️ Adopt a healthy lifestyle, with a balanced diet and regular exercise. ️ Don't smoke or.

Fertility drugs for men | BabyCenter

The majority of patients with inflammatory bowel disease (IBD) are affected during their peak reproductive years.1 While initial concerns focus on attaining a durable remission and avoiding the side effects of medications, once in remission the focus often shifts to the effect of disease and the medications used to treat it on fertility and the ability to conceive a healthy child Fertility Animal data on mesalazine show no effect on male and female fertility. EFFECTS ON ABILITY TO DRIVE AND USE MACHINES Treatment with PENTASA® is unlikely to affect the ability to drive and/or use machines. UNDESIRABLE EFFECTS The most frequent adverse reactions seen in clinical trials are diarrhoea, nausea 4.6 FERTILITY, PREGNANCY AND LACTATION Effects on fertility No effects on fertility or reproductive performance were observed in male or female rats at oral doses of mesalazine up to 400 mg/kg/day (0.7 times the maximum recommended human dose based on a body surface area comparison). Semen abnormalities and infertility in men

Decreased sperm count and impaired sperm motility, which may affect male fertility, have been reported with mesalazine. This effect may be reversible when treatment is discontinued. If you are concerned about this, speak with your doctor. This is not a complete list of all possible side-effects Male Fertility. 1 About you. What type of IBD do you have? Asacol Mesalazine Mesavancol Mezavant Octasa Pentasa Pentasa Retention Enema Pentasa Suppositories Salofalk Sulfasalazine. Acid Surpressant. Esomeprazole Gaviscon Lansoprazole Metoclopramide Omeprazole Ranitidine Zantac. Anti-Sickness

Conservative Nonhormonal Options for the Treatment of Male

However, when 5-ASA was switched to another medication, all male fertility parameters improved after 3 months . Riley et al [ 45 ] reported that among 9 of the 16 men with UC who switched to mesalamine (a 5-ASA compound without the sulfapyridine component), all 9 showed improved semen parameters Male fertility may be reduced on sulfasalazine. Treatment monitoring. Complete blood and platelet count, and renal and liver function tests should be carried out prior to treatment, every two weeks for two months and then every three months thereafter. Pretest for G6PD deficiency outcomes is important for men and women. In women, remission at conception determines better pregnancy outcomes,1,2 and most maternal IBD medication expo-sures are safe.2 In contrast, less is known about the impact of paternal disease activity and medication use on fertility and pregnancy outcomes in men with IBD.3 Method Animal data on mesalazine show no effect on male and female fertility. Oligospermia (reversible) has been reported after use of mesalazine, see section 4.8. Section 4.8 - addition of the subheading: Frequency of adverse effects, based on clinical trials and reports from post-marketing surveillance updates to adverse events as follows Mesalazine was negative in bacterial assays of gene mutation and in a mouse micronucleus test. Impairment of Fertility: Oral administration of mesalazine at doses up to400mg/kg/day to male rats prior to mating and female rats from prior to mating through gestation and lactation did not affect fertility or elicit embryofetal toxicity

Chermesh I and Eliakim R (2004) Mesalazine-induced reversible infertility in a young male. Dig Liver Dis 36 : 551-552 CAS PubMed Article PubMed Central Google Schola Fertility: Animal data on Mesalazine show no effect on male and female fertility 4 . 7 E f f e c t s o n a b i l i t y t o d r i v e a n d u s e m a c h i n e s Pentasa Sachet has no or negligible influence on the ability to drive or use machines The herb has potential negatives impacts on fertility for both men and women. In animal studies, thunder god vine was shown to decrease sperm counts and may impact male fertility . In female mice, thunder god vine was linked to premature ovarian insufficiency , a primary cause of female infertility

4.6 FERTILITY, PREGNANCY AND LACTATION Effects on fertility No effects on fertility or reproductive performance were observed in male or female rats at oral doses of mesalazine of up to 480 mg/kg/day (similar to the maximal recommended human dose of ASACOL on a body surface area basis). Use in pregnancy (Category C Pentasa® (mesalazine) Extended Release Tablets, enemas and suppositories Page 7 of 42 Product Monograph Fertility Semen abnormalities and infertility in men, which are associated with sulfasalazine, have not been reported with PENTASA during controlled clinical trials The term colitis means inflammation of the colon, which people can get after a bad bout of food poisoning for example. Itis added to the end of a word means inflammation, like sinusitis = inflamed sinuses, but doesn't necessarily mean an illness or chronic condition

Sulfasalazine delayed-release (Azulfidine EN-tabs) is also used to treat rheumatoid arthritis in adults and children whose disease has not responded well to other medications. Sulfasalazine is in a class of medications called anti-inflammatory drugs. It works by reducing inflammation (swelling) inside the body Any prescriptions from any other state cannot be filled and will be returned in the mail. Mesasal 250mg Tablets 100 - Mesalazine. Product ID: 2489060. $42.99. Product In High Demand Online. Leaves warehouse in 2-4 business days. Available via Click & Collect. Temporarily low stock online Mesalazine is a key drug in the treatment of ulcerative colitis (UC). Intolerance to mesalazine has been described, including fever and gastrointestinal symptoms. Inflammatory bowel disease in subfertile men and the effect of mesalazine on fertility. Takeshi Shin et al. Systems Biology in Reproductive Medicine. Volume 60, 2014 - Issue 6. Mesalazine (Asacol, Ipocol, Octasa, Pentasa, Salofalk and Mezavant). This 5-ASA comes in different formulations which target slightly different parts of the digestive system. Male fertility can also be affected. So if you are planning to have a baby or especially if you are already pregnant, it is important to check with your IBD team.

PENTASA® (mesalazine) is Ferring's product used for the treatment and long-term management of inflammatory bowel diseases (IBD) (Ulcerative colitis and Crohn's disease). PENTASA is prescribed to treat the mild to moderate symptoms of active IBD as well as being used widely as maintenance therapy to reduce the risk of recurrent attacks Most of these reactions respond to drug withdrawal, although corticosteroid treatment may be required occasionally. Sperm abnormalities have been reported in about 80% of male recipients; these often lead to reduced male fertility, 31, 32 which is especially troublesome for the generally younger male AS population. Mesalazine. Sulfasalazine is. Sulfasalazine leads to reversible male infertility. This effect is temporary and fertility should return to normal levels within two to three months of stopping the medication. There are several good alternatives to sulfasalazine, such as mesalazine, olsalazine or balsalazide, which can usually be used instead Long-term efficacy and safety of once-daily mesalazine granules for the treatment of active ulcerative colitis Stephan Karl Böhm,1 Wolfgang Kruis2 1Kantonsspital Baselland, Medizinische Universitätsklinik, Bruderholz, Switzerland; 2Evangelisches Krankenhaus Kalk, University of Cologne, Cologne, Germany Abstract: In 1977, 5-aminosalicylic acid (5-ASA) was discovered as a therapeutically. Pentasa tablets 500mg contain mesalazine, an aminosalicylate derivative of salicylic acid (aspirin) that is the active component of sulfasalazine. Mesalazine in Pentasa tablets 500mg is a bowel-specific locally acting anti-inflammatory and acts directly on the inflamed intestinal tissue without being absorbed into the blood, so that it has.

Paris, France - October 30, 2007 - For the first time a once daily dosing regime of mesalazine (Pentasa® granules) has proven to be statistically superior to twice daily dosing for the effective maintenance of remission in patients suffering from mild to moderate ulcerative colitis (UC), finds a trial presented at the 15th United European Gastroenterology Week (UEGW) congress Asacol tablets 400mg contain mesalazine, an anti-inflammatory drug that is used to treat inflammatory bowel diseases (IBD), like Crohn's disease and ulcerative colitis, which are chronic inflammatory conditions of the digestive tract, with alternative periods of relapse and remission. Crohn's disease is an autoimmune (when the immune system. Carcinogenesis, Mutagenesis, Impairment Of Fertility. Two-year oral carcinogenicity studies were conducted in male and female F344/N rats and B6C3F1 mice. Sulfasalazine was tested at 84 (496 mg/m2), 168 (991 mg/m2), and 337.5 (1991 mg/m2) mg/kg/day doses in rats

Any prescriptions from any other state cannot be filled and will be returned in the mail. Mesasal 250mg Tablets 100 - Mesalazine. Product ID: 2489060. $52.99. PLEASE NOTE: Product in high demand -. Leaves warehouse in 2-4 business days . Leaves warehouse in 1-2 business days . Temporarily Low Stock Online Methotrexate can be taken as a tablet, liquid or injection. Methotrexate should be taken on the same day once a week. You'll be given a starting dose of methotrexate while your rheumatologist tries to bring your condition under control, but this might be increased if it isn't helping your symptoms.. Methotrexate tablets come in two strengths: 2.5 mg and 10 mg Sulphasalazine and male infertility: reversibility and possible mechanism. Gut 22(6),445-451 (1981). Dejaco C, Mittermaier C, Reinisch W et al. Azathioprine treatment and male fertility in inflammatory bowel disease. Gastroenterology 121(5),1048-1053 (2001). French AE, Koren G; Motherisk Team. Effect of methotrexate on male fertility. Can. Fam Sulfasalazine is an azobenzene consisting of diphenyldiazene having a carboxy substituent at the 4-position, a hydroxy substituent at the 3-position and a 2-pyridylaminosulphonyl substituent at the 4'-position. It has a role as a non-steroidal anti-inflammatory drug, an antiinfective agent, a gastrointestinal drug, an EC 2.5.1.18 (glutathione transferase) inhibitor and a drug allergen

Carcinogenesis, Mutagenesis, Impairment Of Fertility: Two-year oral carcinogenicity studies were conducted in male and female F344/N rats and B6C3F1 mice. Sulfasalazine was tested at 84 (496 mg/m²), 168 (991 mg/m²), and 337.5 (1991 mg/m²) mg/kg/day doses in rats FERTILITY. Fertility is probably normal in women with ulcerative colitis. In inactive Crohn's disease, the evidence also suggests normal fertility but Crohn's disease activity impairs fertility. 9 Men and women with IBD have been shown to have fewer children than unaffected individuals. 7 In one study which examined pregnancy in women with IBD who became pregnant before or after the diagnosis. We provide a basic overview of inheritance, fertility and influence of IBD and pregnancy, therapy in pregnancy and childbirth options. A crucial factor for good results is the degree of inflammation at the time of conception and during pregnancy. If the disease is inactive, there is no decrease in fertility and no greater risk of deterioration of disease in pregnancy and pregnancy does not. Objective. To carry out a systematic analysis of the data available in the world literature on the effects of various groups of drugs used in therapy for immune-mediated inflammatory rheumatic diseases (IMIRDs) on the female and male reproductive system, as well as methods to preserve reproductive function in this patient contingent

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